CONSERVATION OF ANCESTRAL HAPLOTYPES TELOMERIC OF HLA‐A
Identifieur interne : 00CE73 ( Main/Exploration ); précédent : 00CE72; suivant : 00CE74CONSERVATION OF ANCESTRAL HAPLOTYPES TELOMERIC OF HLA‐A
Auteurs : G. K. Tay [Australie] ; S. K. Cattley [Australie] ; M. J. Chorney [États-Unis] ; P. N. Hollingsworth [Australie] ; M. P. Roth [France] ; R. L. Dawkins [Australie] ; C. S. Witt [Australie]Source :
- European Journal of Immunogenetics [ 0960-7420 ] ; 1997-08.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Association, Génétique, Homme, Immunologie.
English descriptors
- KwdEn :
- Allele, Allele frequencies, Allele size, Ancestral, Ancestral haplotype, Ancestral haplotypes, Asia oceania histocompatibility workshop number, Association, Blackwell science, Cell lines, Cell panel, Characteristic alleles, Chromosome C6, Class I histocompatibility antigen, Consanguineous marriages, Conservation ofhaplotypes, Dawkins, Diabetes mellitus, European journal ofimmunogenetics, Gene, Genetic mapping, Genetics, HLA-A-Locus, HLA-System, Haemochromatosis, Haemochromatosis gene, Haplotype, Hemochromatosis, Histocompatibility, Homozygous cell lines, Homozygous cells, Human, Human immunology, Immunogenetics, Immunology, International histocompatibility workshop number, Local identification number, Locus, Major histocompatibility system, Microsatellite, Microsatellite alleles, Microsatellite loci, Molecular immunology, Nature genetics, Ofimmunogenetics, Other cells, Phenotype, Present study, Recombinant, Recombinant mapping, Recombination, Risk factor, Slippage, Susceptibility, Susceptibility genes, Telomeric, Western australia.
- Teeft :
- Allele, Allele frequencies, Allele size, Ancestral, Ancestral haplotype, Ancestral haplotypes, Asia oceania histocompatibility workshop number, Blackwell science, Cell lines, Cell panel, Characteristic alleles, Consanguineous marriages, Conservation ofhaplotypes, Dawkins, Diabetes mellitus, European journal ofimmunogenetics, Genetics, Haemochromatosis, Haemochromatosis gene, Haplotype, Histocompatibility, Homozygous cell lines, Homozygous cells, Human immunology, Immunogenetics, Immunology, International histocompatibility workshop number, Local identification number, Locus, Microsatellite, Microsatellite alleles, Microsatellite loci, Molecular immunology, Nature genetics, Ofimmunogenetics, Other cells, Phenotype, Present study, Recombinant, Recombinant mapping, Recombination, Slippage, Susceptibility, Susceptibility genes, Telomeric, Western australia.
Abstract
Genes that predispose to haemochromatosis are thought to be located within the several megabases telomeric of HLA‐A. Further recombinant mapping has been used previously to map susceptibility genes for diseases such as insulin‐dependent diabetes mellitus, myasthenia gravis and cystic fibrosis, and should be useful in relation to haemochromatosis. However, this method requires the recognition of ancestral haplotypes within the susceptibility region. Using a panel of six microsatellite markers from this region (MOG A, MOG B, MOG C, D6S464, D6S306 and D6S105), we show that ancestral haplotypes extend telomeric of HLA‐A, at least as far as D6S105. Nine of 14 haplotypes carrying HLA‐B7 and HLA‐A3 shared the same microsatellite alleles between HLA‐A and at least D6S105. Similarly, nine of 10 haplotypes sharing HLA‐B8 and HLA‐A1 shared the same microsatellite alleles, although a different set to those with HLA‐B7 and HLA‐A3. Haplotypes representing historical recombination events were also identified. These two findings demonstrate that recombinant mapping may be applicable to the mapping of disease genes in this region.
Url:
DOI: 10.1111/j.1365-2370.1997.tb00021.x
Affiliations:
- Australie, France, États-Unis
- Australie-Occidentale, Midi-Pyrénées, Occitanie (région administrative), Pennsylvanie
- Toulouse
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K." last="Tay">G. K. Tay</name><affiliation wicri:level="2"><country>Australie</country><placeName><region type="state">Australie-Occidentale</region></placeName><wicri:cityArea>Centre for Molecular Immunology and Instrumentation, The University of Western Australia and The Departments of Clinical Immunology, Royal Perth Hospital and Sir Charles Gairdner Hospital, Perth</wicri:cityArea></affiliation></author><author><name sortKey="Cattley, S K" sort="Cattley, S K" uniqKey="Cattley S" first="S. K." last="Cattley">S. K. Cattley</name><affiliation wicri:level="2"><country>Australie</country><placeName><region type="state">Australie-Occidentale</region></placeName><wicri:cityArea>Centre for Molecular Immunology and Instrumentation, The University of Western Australia and The Departments of Clinical Immunology, Royal Perth Hospital and Sir Charles Gairdner Hospital, Perth</wicri:cityArea></affiliation></author><author><name sortKey="Chorney, M J" sort="Chorney, M J" uniqKey="Chorney M" first="M. J." last="Chorney">M. J. Chorney</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Microbiology and Immunology and Pediatrics, College of Medicine, University Hospital and Childrens Hospital, The Milton S. Hershey Medical Center, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Hollingsworth, P N" sort="Hollingsworth, P N" uniqKey="Hollingsworth P" first="P. N." last="Hollingsworth">P. N. Hollingsworth</name><affiliation wicri:level="2"><country>Australie</country><placeName><region type="state">Australie-Occidentale</region></placeName><wicri:cityArea>Centre for Molecular Immunology and Instrumentation, The University of Western Australia and The Departments of Clinical Immunology, Royal Perth Hospital and Sir Charles Gairdner Hospital, Perth</wicri:cityArea></affiliation></author><author><name sortKey="Roth, M P" sort="Roth, M P" uniqKey="Roth M" first="M. P." last="Roth">M. P. Roth</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CIGH, CNRS UPR, CHU Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Dawkins, R L" sort="Dawkins, R L" uniqKey="Dawkins R" first="R. L." last="Dawkins">R. L. Dawkins</name><affiliation wicri:level="2"><country>Australie</country><placeName><region type="state">Australie-Occidentale</region></placeName><wicri:cityArea>Centre for Molecular Immunology and Instrumentation, The University of Western Australia and The Departments of Clinical Immunology, Royal Perth Hospital and Sir Charles Gairdner Hospital, Perth</wicri:cityArea></affiliation><affiliation><wicri:noCountry code="subField">6008.</wicri:noCountry></affiliation></author><author><name sortKey="Witt, C S" sort="Witt, C S" uniqKey="Witt C" first="C. S." last="Witt">C. S. Witt</name><affiliation wicri:level="2"><country>Australie</country><placeName><region type="state">Australie-Occidentale</region></placeName><wicri:cityArea>Centre for Molecular Immunology and Instrumentation, The University of Western Australia and The Departments of Clinical Immunology, Royal Perth Hospital and Sir Charles Gairdner Hospital, Perth</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">European Journal of Immunogenetics</title><title level="j" type="alt">EUROPEAN JOURNAL OF IMMUNOGENETICS</title><idno type="ISSN">0960-7420</idno><idno type="eISSN">1365-2370</idno><imprint><biblScope unit="vol">24</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="275">275</biblScope><biblScope unit="page" to="285">285</biblScope><biblScope unit="page-count">11</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1997-08">1997-08</date></imprint><idno type="ISSN">0960-7420</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0960-7420</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Allele</term><term>Allele frequencies</term><term>Allele size</term><term>Ancestral</term><term>Ancestral haplotype</term><term>Ancestral haplotypes</term><term>Asia oceania histocompatibility workshop number</term><term>Association</term><term>Blackwell science</term><term>Cell lines</term><term>Cell panel</term><term>Characteristic alleles</term><term>Chromosome C6</term><term>Class I histocompatibility antigen</term><term>Consanguineous marriages</term><term>Conservation ofhaplotypes</term><term>Dawkins</term><term>Diabetes mellitus</term><term>European journal ofimmunogenetics</term><term>Gene</term><term>Genetic mapping</term><term>Genetics</term><term>HLA-A-Locus</term><term>HLA-System</term><term>Haemochromatosis</term><term>Haemochromatosis gene</term><term>Haplotype</term><term>Hemochromatosis</term><term>Histocompatibility</term><term>Homozygous cell lines</term><term>Homozygous cells</term><term>Human</term><term>Human immunology</term><term>Immunogenetics</term><term>Immunology</term><term>International histocompatibility workshop number</term><term>Local identification number</term><term>Locus</term><term>Major histocompatibility system</term><term>Microsatellite</term><term>Microsatellite alleles</term><term>Microsatellite loci</term><term>Molecular immunology</term><term>Nature genetics</term><term>Ofimmunogenetics</term><term>Other cells</term><term>Phenotype</term><term>Present study</term><term>Recombinant</term><term>Recombinant mapping</term><term>Recombination</term><term>Risk factor</term><term>Slippage</term><term>Susceptibility</term><term>Susceptibility genes</term><term>Telomeric</term><term>Western australia</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Antigène histocompatibilité classe I</term><term>Association</term><term>Carte génétique</term><term>Chromosome C6</term><term>Facteur risque</term><term>Gène</term><term>Haplotype</term><term>Homme</term><term>Hémochromatose</term><term>Locus HLA-A</term><term>Système HLA</term><term>Système histocompatibilité majeur</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Allele</term><term>Allele frequencies</term><term>Allele size</term><term>Ancestral</term><term>Ancestral haplotype</term><term>Ancestral haplotypes</term><term>Asia oceania histocompatibility workshop number</term><term>Blackwell science</term><term>Cell lines</term><term>Cell panel</term><term>Characteristic alleles</term><term>Consanguineous marriages</term><term>Conservation ofhaplotypes</term><term>Dawkins</term><term>Diabetes mellitus</term><term>European journal ofimmunogenetics</term><term>Genetics</term><term>Haemochromatosis</term><term>Haemochromatosis gene</term><term>Haplotype</term><term>Histocompatibility</term><term>Homozygous cell lines</term><term>Homozygous cells</term><term>Human immunology</term><term>Immunogenetics</term><term>Immunology</term><term>International histocompatibility workshop number</term><term>Local identification number</term><term>Locus</term><term>Microsatellite</term><term>Microsatellite alleles</term><term>Microsatellite loci</term><term>Molecular immunology</term><term>Nature genetics</term><term>Ofimmunogenetics</term><term>Other cells</term><term>Phenotype</term><term>Present study</term><term>Recombinant</term><term>Recombinant mapping</term><term>Recombination</term><term>Slippage</term><term>Susceptibility</term><term>Susceptibility genes</term><term>Telomeric</term><term>Western australia</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term><term>Génétique</term><term>Homme</term><term>Immunologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genes that predispose to haemochromatosis are thought to be located within the several megabases telomeric of HLA‐A. Further recombinant mapping has been used previously to map susceptibility genes for diseases such as insulin‐dependent diabetes mellitus, myasthenia gravis and cystic fibrosis, and should be useful in relation to haemochromatosis. However, this method requires the recognition of ancestral haplotypes within the susceptibility region. Using a panel of six microsatellite markers from this region (MOG A, MOG B, MOG C, D6S464, D6S306 and D6S105), we show that ancestral haplotypes extend telomeric of HLA‐A, at least as far as D6S105. Nine of 14 haplotypes carrying HLA‐B7 and HLA‐A3 shared the same microsatellite alleles between HLA‐A and at least D6S105. Similarly, nine of 10 haplotypes sharing HLA‐B8 and HLA‐A1 shared the same microsatellite alleles, although a different set to those with HLA‐B7 and HLA‐A3. Haplotypes representing historical recombination events were also identified. These two findings demonstrate that recombinant mapping may be applicable to the mapping of disease genes in this region.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>États-Unis</li></country><region><li>Australie-Occidentale</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Pennsylvanie</li></region><settlement><li>Toulouse</li></settlement></list><tree><country name="Australie"><region name="Australie-Occidentale"><name sortKey="Tay, G K" sort="Tay, G K" uniqKey="Tay G" first="G. K." last="Tay">G. K. Tay</name></region><name sortKey="Cattley, S K" sort="Cattley, S K" uniqKey="Cattley S" first="S. K." last="Cattley">S. K. Cattley</name><name sortKey="Dawkins, R L" sort="Dawkins, R L" uniqKey="Dawkins R" first="R. L." last="Dawkins">R. L. Dawkins</name><name sortKey="Hollingsworth, P N" sort="Hollingsworth, P N" uniqKey="Hollingsworth P" first="P. N." last="Hollingsworth">P. N. Hollingsworth</name><name sortKey="Witt, C S" sort="Witt, C S" uniqKey="Witt C" first="C. S." last="Witt">C. S. Witt</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Chorney, M J" sort="Chorney, M J" uniqKey="Chorney M" first="M. J." last="Chorney">M. J. Chorney</name></region></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Roth, M P" sort="Roth, M P" uniqKey="Roth M" first="M. P." last="Roth">M. P. Roth</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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